H2N2V1, 1957, Analysis, bibRecord, 000013

Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis

Identifieur interne : 000013 ( 1957/Analysis ); précédent : 000012; suivant : 000014

Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis

Auteurs : Martha I. Nelson [États-Unis] ; Michael Worobey [États-Unis]

Source :

American Journal of Epidemiology [ 0002-9262 ] ; 2018.

RBID : PMC:6269246

Abstract

How influenza A viruses host-jump from animal reservoir species to humans, which can initiate global pandemics, is a central question in pathogen evolution. The zoonotic and spatial origins of the influenza virus associated with the “Spanish flu” pandemic of 1918 have been debated for decades. Outbreaks of respiratory disease in US swine occurred concurrently with disease in humans, raising the possibility that the 1918 virus originated in pigs. Swine also were proposed as “mixing vessel” intermediary hosts between birds and humans during the 1957 Asian and 1968 Hong Kong pandemics. Swine have presented an attractive explanation for how avian viruses overcome the substantial evolutionary barriers presented by different cellular environments in humans and birds. However, key assumptions underpinning the swine mixing-vessel model of pandemic emergence have been challenged in light of new evidence. Increased surveillance in swine has revealed that human-to-swine transmission actually occurs far more frequently than the reverse, and there is no empirical evidence that swine played a role in the emergence of human influenza in 1918, 1957, or 1968. Swine-to-human transmission occurs periodically and can trigger pandemics, as in 2009. But swine are not necessary to mediate the establishment of avian viruses in humans, which invites new perspectives on the evolutionary processes underlying pandemic emergence.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269246

DOI: 10.1093/aje/kwy150
PubMed: 30508193
PubMed Central: 6269246

Affiliations:

Links to Exploration step

PMC:6269246

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis</title>
<author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I" last="Nelson">Martha I. Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="AF0001">Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Worobey, Michael" sort="Worobey, Michael" uniqKey="Worobey M" first="Michael" last="Worobey">Michael Worobey</name>
<affiliation wicri:level="2"><nlm:aff id="AF0002">Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Ecology and Evolutionary Biology, University of Arizona, Tucson</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30508193</idno>
<idno type="pmc">6269246</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269246</idno>
<idno type="RBID">PMC:6269246</idno>
<idno type="doi">10.1093/aje/kwy150</idno>
<date when="2018">2018</date>
<idno type="wicri:Area/Pmc/Corpus">000C71</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C71</idno>
<idno type="wicri:Area/Pmc/Curation">000C71</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C71</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000121</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000121</idno>
<idno type="wicri:Area/Ncbi/Merge">000F40</idno>
<idno type="wicri:Area/Ncbi/Curation">000F40</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F40</idno>
<idno type="wicri:doubleKey">0002-9262:2018:Nelson M:origins:of:the</idno>
<idno type="wicri:Area/Main/Merge">000170</idno>
<idno type="wicri:Area/Main/Curation">000170</idno>
<idno type="wicri:Area/Main/Exploration">000170</idno>
<idno type="wicri:Area/1957/Extraction">000013</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis</title>
<author><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I" last="Nelson">Martha I. Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="AF0001">Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Worobey, Michael" sort="Worobey, Michael" uniqKey="Worobey M" first="Michael" last="Worobey">Michael Worobey</name>
<affiliation wicri:level="2"><nlm:aff id="AF0002">Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Ecology and Evolutionary Biology, University of Arizona, Tucson</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Epidemiology</title>
<idno type="ISSN">0002-9262</idno>
<idno type="eISSN">1476-6256</idno>
<imprint><date when="2018">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>How influenza A viruses host-jump from animal reservoir species to humans, which can initiate global pandemics, is a central question in pathogen evolution. The zoonotic and spatial origins of the influenza virus associated with the “Spanish flu” pandemic of 1918 have been debated for decades. Outbreaks of respiratory disease in US swine occurred concurrently with disease in humans, raising the possibility that the 1918 virus originated in pigs. Swine also were proposed as “mixing vessel” intermediary hosts between birds and humans during the 1957 Asian and 1968 Hong Kong pandemics. Swine have presented an attractive explanation for how avian viruses overcome the substantial evolutionary barriers presented by different cellular environments in humans and birds. However, key assumptions underpinning the swine mixing-vessel model of pandemic emergence have been challenged in light of new evidence. Increased surveillance in swine has revealed that human-to-swine transmission actually occurs far more frequently than the reverse, and there is no empirical evidence that swine played a role in the emergence of human influenza in 1918, 1957, or 1968. Swine-to-human transmission occurs periodically and can trigger pandemics, as in 2009. But swine are not necessary to mediate the establishment of avian viruses in humans, which invites new perspectives on the evolutionary processes underlying pandemic emergence.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Nelson, Martha I" sort="Nelson, Martha I" uniqKey="Nelson M" first="Martha I" last="Nelson">Martha I. Nelson</name>
</region>
<name sortKey="Worobey, Michael" sort="Worobey, Michael" uniqKey="Worobey M" first="Michael" last="Worobey">Michael Worobey</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000013 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000013 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    1957
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:6269246
   |texte=   Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i   -Sk "pubmed:30508193" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis

Origins of the 1918 Pandemic: Revisiting the Swine “Mixing Vessel” Hypothesis

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.